If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

In this volume specialists of medieval music and philosophy put the medieval 'musica' into the context of ideas and institutions in which it existed. The significance of 'musica' cannot be understood from a modern point of view since 'music' does not match the medieval 'musica'.

The 21st Century Cures Act is a major act of legislation that contains numerous changes to drug and device regulation. The House of Representatives passed the Act after considerable interest group lobbying, but the bill and the key changes made during its drafting remain controversial. Using publicly disclosed records of written comments on the bill, we reviewed the key areas of lobbying activity and the compromises made in the final text. We focused on legislative provisions relating to management of the (...) National Institutes of Health, incentives for medical product development, and approval standards for new drugs and devices. By the end of the first comment period, the Committee received 118 comments. Most respondents were patient organizations, professional societies, and pharmaceutical and device companies. Overall, the majority of public comments were positive, although public health and consumer organizations were underrepresented in the number of submitted comments. As the legislative process continued, the draft bill underwent several changes relating to NIH funding, market exclusivity provisions, and scrutiny of regulatory evidentiary standards. Understanding the key statutory provisions and how they have evolved could help patients, researchers, and advocates make more informed comments on the bill and future health care legislation. (shrink)

There has been a long tradition of characterizing man as the animal that talks. However, the remarkable ability of using pictures also only belongs to human beings, after all we know empirically so far. Are there conceptual reasons for that coincidence? Such a question belongs to the philosophy of language just as well as to philosophical visualistics. Comparing the two abilities to use words or pictures yields several similarities as well as distinctions. A well-known conceptual disparity between pictures and words (...) appears in their relation to perception: the difference can be further determined in an act-theoretic manner by four modes of use of the sign vehicles during the corresponding sign acts. Furthermore, the figure/ground dichotomy means something different for language uses and picture uses. In both cases, however, there is a close relation to the function of context building, by which humans are able to communicate not only with respect to the present situation of behavior but with respect to arbitrary contexts as well. Although the structural comparison does clarify the conceptual relations, it cannot explain that the conceptual structure ought to be like that. Therefore, the paper concludes with the programme of a "concept-genetic" consideration of the two abilities (i.e., to use propositional language or to use pictures) that is able to give us such a foundation. (shrink)

There has been a long tradition of characterizing man as the animal that is capable of propositional language. However, the remarkable ability of using pictures also only belongs to human beings. Both faculties however depend conceptually on the ability to refer to absent situations by means of sign acts called 'context building'. The paper investigates the combined roles of quasi-pictorial sign acts and proto-assertive sign acts in the situation of initial context building, which, in the context of “concept-genetic” considerations, aims (...) for a philosophical explanation of the anthropological functon of pictures and their relation to imagination. (shrink)

There has been a long tradition of characterizing man as the animal that talks. However, the remarkable ability of using pictures also only belongs to human beings, after all we know empirically so far. Are there conceptual reasons for that coincidence? The paper is dedicated to a philosophical programme of “concept-genetic” considerations dealing in particular with the dependencies between those two abilities: The conceptual relation between the competence to use assertive language and the faculty of employing pictures must be conceived (...) of as being much closer than usually expected. Indeed we conclude, there cannot be creatures with only one of them. (shrink)

There is a long tradition of characterizing man as the talking animal. However, the remarkable ability of using pictures also belongs to human beings, after all we know empirically so far. Are there conceptual reasons for that coincidence? Such a question belongs to the general science of language (linguistics) and philosophy of language just as well as to general visualistics (image science) - a discipline just emancipating itself from art history. We here take the visualistics point of view. A first (...) recapitulation of the two abilities to use words or pictures lists several similarities and distinctions. A well-known disparity between pictures and words in the relation to perception can be determined by differences in the modes of usage during the corresponding sign acts. Furthermore, there are distinct ways for splitting up the pictorial or verbal sign acts into figure and ground. Such a structural comparison can only clarify conceptual relations; it cannot explain that the conceptual structure ought to be like that, in contrast to concept-genetic considerations. Correspondingly the discussion is extended to a concept-genetic sketch of the abilities to use language or pictures. This shifts the focus of attention to the concept of sortal objects and the concept of contexts of behavior. They allow us to analyze more precisely the relation between the two abilities in question, in particular as something depending on the function of context building, which enables human beings to communicatively access contexts apart from the actual situation of behavior. We finally gain arguments that characterize that relation as one of mutual dependency, and even lead to an understanding of the concept of inner images - or rather: a concept of imagination. (shrink)

We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

Was die Frage nach der Funktion der Sprache im Erkenntnisprozeß betrifft, haben wir zuerst die verschiedenen Theorien dargestellt. Nach einer Reihe alleinstehender Personen wie Derbolav, Bühler, Jost, Glinz behandeln wir die Strömungen der symbolischen Logik und der linguistic analysis. Die symbolische Logik will das Denken in einer logischen Modellsprache analysieren. Die linguistic Analysis betrachtet die gewöhnliche Umgangssprache als Trägerin des Denkens und will, daß alle Philosophen und Wissenschaftler sich in dieser gewöhnlichen Umgangssprache ausdrücken, die bei guter Analyse für jeden intelligenten (...) Menschen verständlich ist. Die Strömungen der Phänomenologie und des Existentialismus äußern die Erfahrung, daß der Mensch seine Existenz ganz in einer sprechenden Welt erfährt und daß sich seine Existenz in der Sprache vollzieht : die Sprache ist das Haus seines Daseins. Keine Sache kann in unserem Bewußtsein zur Existenz gelangen, wenn wir sie nicht zu Wort bringen können. Die Ethnolinguisten und Psycholinguisten sind zu dem Ergebnis gekommen, daß die Formen, in denen ein Mensch jeweils denkt, von den unerbittlichen und unentrinnbaren Strukturen der Wörter mit ihren Bedeutungen und den Strukturen der Wortkombinationen kontrolliert werden. Diese Strukturen sind die Strukturen der jeweiligen Muttersprache. Das Denken eines Menschen vollzieht sich in seiner Sprache. Die Strukturen der Sprache liefern die Modelle für das Denken, für die Analyse der Eindrücke. Unser ganzes Denken bewegt sich in einer denkerisch-sprachigen Welt. Jedes Denken muß sich in Sprachstrukturen kanalisieren lassen. Die Sprache ist das formgebende Organ des Denkens. Die Denkanalyse vollzieht sich in Sprache. In einem bestimmten Augenblick der Entwicklung des Kindes begegnen sich Sprache und Denken ; dann wird das Denken „sprachig” und das Sprechen „denkerisch”. Von nun an werden die meisten Reize der physischen Welt durch ein sprachiges zweites Reizsystem gefiltert ; die Reize werden „in Sprache übersetzt”. Dieser Sprachfilter ist auch in der Analyse nach der dynamischen Erfassung der Reize vorhanden. Diese Daten aus den Theorien der Linguistic Analysis, der Phänomenologie, des Existentialismus, der Ethnolinguistik und Psycholinguistik kann man in direkte Verbindung bringen mit der neoklassischien Theorie, die über ein Erfassen von Erkenntnis-Daten in einer Intuition spricht, die implizit die Möglichkeit zu einem Explizitieren und Analysieren enthält. Somit kommen wir zu folgendem Schema : Reize, sprachiger Empfangsapparat ↓ Erfassung der Reize, Konzeption, Sicht ↓ Denk-Sprachanalyse ↓ Die phonische Äußerung der Denk-Sprachanalyse. Zum Schluß geben wir noch ein Beispiel für eine Kons ta tierungs-Sicht, Ihre Denk-Sprachanalyse und die phonische Äußerung ihrer Denk-Sparchanalyse. (shrink)

This volume, which contains the 1962 lecture "Zeit und Sein," is the most important publication by Heidegger since Unterwegs zur Sprache appeared in 1959. Bearing the same title as the much discussed missing part of the first half of Sein und Zeit, "Zeit und Sein" is the best demonstration we have of how the later Heidegger carries out the program which was outlined in Sein und Zeit, i.e., how the clue which the analytic of Dasein provides--that Being is to be (...) understood in terms of time--is followed out in the later works. Heidegger explicates the temporality of Being in terms of its character as a "gift" and an epochal sending which "is" both as having been and as to come. Being as time is thus the "event of appropriation". In addition to "Zeit und Sein," Zur Sache des Denkens also contains: The notes of a seminar which Heidegger conducted at Todtnauberg in 1962 upon the "Zeit und Sein" lecture. As Professor Alfredo Guzzoni, the editor of these notes, indicates this is the only time that Heidegger has conducted a seminar on a text of his own composition. A lecture entitled "The End of Philosophy and the Problem of Thought," which was delivered at a Kierkegaard colloquium in 1964. An autobiographical description of Heidegger's growing interest in and attraction to Husserl's phenomenological method in the pre-Sein und Zeit period; this was prepared in 1963 for a Festschrift in honor of Hermann Niemeyer.--J. D. C. (shrink)

Julius Sachs (1832–1897), who has been quite rightly called “the father of plant physiology,” was a German physiologist of international standing, whose research interests contributed to virtually every branch of the plant sciences, and whose work presaged plant molecular biology and systems biology. Here, we focus on one of his last publications, from 1892, wherein he argued that the term “cell” (_Zelle_) is misleading and should be replaced by “energid” (_Energide_), which he defined as “a nucleus together with the (...) corresponding protoplasm that is governed by it,” based on his observations of coenocytic algae such as _Caulerpa_ whose nuclei “can only control” so much cytoplasm. Although most of his colleagues did not accept this novel terminology for the description of the “basic, minimal living unit” (_Elementarorganismus_) of animals, plants, and microbes, we argue that the energid concept prefigured the subsequent discovery of mRNA. We also argue that the resistance to the energid concept revolved around a deep-seated philosophical debate between those adhering to cell theory versus organismal theory. The first English translation of the seminal work by Sachs, “Physiologische Notizen. II. Beiträge zur Zellentheorie. a) Energiden und Zellen,” originally published in _Flora_ (75: 57–67, 1892), is provided as a separate article in this volume as part of the journal’s “Classics in Biological Theory” collection ( https://doi.org/10.1007/s13752-022-00399-w ); the original German version is available here as supplementary material in the online version of this article. (shrink)

The evolution of biparental sexual reproduction in animals and plants is a prominent focus in modern biology. One hundred and fifty years ago, the German biologist Julius Sachs (1832–1897) published the fourth and final edition of his influential _Textbook of Botany_. In the text, he referred to the work of Wilhelm Hofmeister (1824–1877) and proposed that it is possible to reconstruct the origins and evolution of sexuality via systematic comparisons among the life cycles of simple versus complex organisms. (...) class='Hi'>Sachs’s 1874 book presented the green alga _Pandorina_ as an example of ancestral life cycles, and that of the land plants as the most complex photosynthetic organisms. Herein, we describe the 150-year-old hypothesis proposed by Sachs and show how the purported “architect of modern plant physiology” provided insights into (1) recent papers implicating the role of HMG-box genes for the expression of male versus female sex determination in complex eukaryotes, such as animals, brown algae, and fungi; and (2) the continuing debate about the meaning of homology in the context of evolution. We conclude that the physiologist Sachs, along with Hofmeister, was also one of the founders of comparative sex research in animals and plants. (shrink)

Although prenatal screening is routinely undertaken as part of a woman's antenatal care, the ethics surrounding it are complex. In this paper, the author examines the Jewish position on the permissibility of several tests, including those for Down's syndrome and Tay-Sachs disease, the latter being especially common in the Jewish community. Clearly, the status of the tests depends on whether termination of affected pregnancies is allowed, and contemporary rabbinical authorities are themselves in dispute as to the permissibility of terminating (...) affected pregnancies. The nature of these arguments is examined and the author concludes that there are grounds on which the full range of prenatal screening is permitted in Jewish law. (shrink)

Localised configurations of the free electromagnetic field are constructed, possessing properties of massive, spinning, relativistic particles. In an inertial frame, each configuration travels in a straight line at constant speed, less than the speed of lightc, while slowly spreading. It eventually decays into pulses of radiation travelling at speedc. Each configuration has a definite rest mass and internal angular momentum, or spin. Each can be of “electric” or “magnetic” type, according as the radial component of the magnetic or electric field (...) vanishes in the rest frame, and each has an “antiparticle.” Any such configuration, of electric or magnetic type, is characterized in part by a set of labels (κ, ω0, σ,l, m), where ω0 is the mean of the angular frequencies of the plane waves making up the configuration, σ is the variance of those frequencies, κ is a positive constant with dimensions of action, andl, m are angular momentum “quantum numbers” withl a positive integer andm an integer such that ‖m‖≤l. The rest energy of the “particle” is κω0, its spin is κ ‖m‖, and its lifetime is of the order of 1/σ. Its antiparticle has ω0 replaced by −ω0. (shrink)

Phantom limb experiences demonstrate an unexpected degree of fragility inherent in our self-perceptions. This is perhaps most extreme when congenitally absent limbs are experienced as phantoms. Aplasic phantoms highlight fundamental questions about the physiological bases of self-experience and the ontogeny of a physical, embodied sense of the self. Some of the most intriguing of these questions concern the role of mirror neurons in supporting the development of self–other mappings and hence the emergence of phantom experiences of congenitally absent limbs. In (...) this paper, we will examine the hypothesis that aplasic phantom limb experience is the result of an ontogenetic interplay between body schemas and mirror neuron activity and that this interplay is founded on embedding in a social context. Phantom limb experience has been associated with the persistence of subjective experience of a part of the body after deafferentation through surgical or traumatic removal. We maintain that limited association is inconsistent with the extent to which phantom limb experience is reported by aplasic individuals. (shrink)

Heideggerian thought is routinely understood to involve an insistence on finitude, and a rejection of the metaphysical priority of the infinite. As a general rule, this characterization is adequate, but it risks a significant oversimplification of a complex theme in Heidegger’s thinking. After an initial discussion of his dominant position on (in)finitude, the paper focuses on a number of largely neglected and some recently published texts concerning Heidegger’s retrieval of the inheritance of the Greek and Latin grammar of Being, as (...) well as the origins of the idea of the infinite in Anaximander’s ἄπειρον. These texts reveal some important tensions in Heideggerian thought on the status of infinitude in its relation to die Sache selbst of that thought. (shrink)

Deterministic models in population dynamics often are really approximations to stochastic models, justified by an appeal to the law of large numbers. It is proposed to call such models pseudodeterministic. Four questions are discussed in this article: (1) What errors may be made by equating deterministically predicted values to expectations? (2) When, and in what sense, may numbers be assumed to be large? (3) How large are the variances, coefficients of variations, etc., as assigned to the variables in the stochastic (...) versions of the models? (4) What role may pseudodeterministic models play in empirical research, where problems of statistical reliability arise?As an example, a modified Nicholson-Bailey model of the interaction between insect parasitoids and their hosts is discussed; the modification consists of assigning a random (density-independent) mortality to the parasitoid population. A stochastic version of this model is discussed. The expectation of the final host density is compared with the value computed from the deterministic model. The latter value is systematically lower than the former. The magnitude of the difference depends on parameter values. The variability to be expected with the stochastic model is characterized by the coefficient of variation of the final host density; its dependence on parameter values and initial conditions is discussed. It is concluded that it is worthwhile in practical applications to estimate parasitoid mortality, and that the coefficient of variation in real situations may be far from negligible. (shrink)

This book addresses the theme of global sustainable development across two dimensions.First it introduces its progress and prospects in both rich and poor countries. It then outlines the major trends that will in practice influence the direction of sustainable development into the next century. It encompasses an understanding of sustainable development as both a theoretical framework for thinking about how to deal with human needs and environmental limits on the one hand, and a more material understanding of it as a (...) set of practices, on the other.The book is written by a group of internationally-recognised experts in the field, and is distinctive in offering a variety of philosophical and ethical reflections on sustainable development. Core issues covered include economic growth, poverty reduction, future generations, technology, population and diversity, making it an ideal text for students.Key Features: The only available text to introduce the philosophical and ethical issues surrounding sustainable developmentContributors are internationally-renowned experts in the field and include activists and policy makers, as well as academicsCore areas include global equality, technology, women and populationAn ideal course textbook for Politics, Philosophy and International Relations student. (shrink)

L'oubli est précédé par sa mauvaise réputation. Pensé comme un manque de la mémoire, le symptôme d'une dégénérescence annoncée, on le redoute. On cherche à l'oublier bien que l'on sache qu'il sera toujours là. Pourtant, s'il ne faisait pas quotidiennement son œuvre, on ne pourrait plus vivre, agir ou créer. Oublier est une faculté universelle et vitale dont les modalités d'expression diffèrent de celles de la mémoire : une puissance enfouie en notre être, une force créatrice capable de nous régénérer. (...) À contre-courant des modes et humeurs de notre société, des philosophes, des anthropologues et surtout des artistes n'ont pas oublié d'oublier tous les fardeaux qui se présentent comme des obstacles à leur désir de création. Développer sa capacité à effacer les évènements pesants et traumatisants qui nous conduisent au désastre est moins un risque qu'un pari, dont l'enjeu est de rendre à chaque personne ce qu'elle désire peut-être le plus au monde : affirmer sa réelle singularité, notamment par et dans l'acte créatif."--Page 4 of cover. (shrink)

In this paper we describe a test for Nijhout's hypothesis that the eyespot patterns on butterfly wings are the result of a threshold reaction of the epidermal cells to a concentration gradient of a diffusing degradable morphogen produced by focal cells at the centre of the future eyespot. The wings of the nymphalid butterfly, Bicyclus anynana, have a series of eyespots, each composed of a white pupil, a black disc and a gold outer ring. In earlier extirpation and transplantation experiments (...) it has been established that these eyespots are indeed organised around groups of signalling cells active during the first hours of pupal development. If these cells were to supply the positional information for eyespot formation in accordance with Nijhout's diffusion-degradation gradient model, then, when two foci are close together, the signals should sum, and this effect should be apparent in the detailed shape of the resulting pigment pattern. We give an equation for the form of the contours that would be obtained in this manner. We use this to test the morphogen gradient hypothesis on measurements of the outlines of fused eyespots obtained either by grafting focal cells close together, or by using a mutation that produces adjacent fused eyespots. The contours of the fused patterns were found to satisfy our equation, thus corroborating Nijhout's hypothesis to the extent possible with this particular type of experiment. (shrink)